Studies on Fermentative Biotic Production of Ergot Alkaloids

Abstract

In comparison to submerged fermentation, Claviceps fusiformis produced 3.9 times more total ergot alkaloids during solid-state fermentation. The production of Claviceps purpurea was equal, but the range of alkaloids was expanded through solid-state fermentation. The natural compounds called indole alkaloids, or ergot alkaloids, are nitrogen-containing substances.  Fungi belonging to the phylum Ascomycota, including Claviceps, Epichloë, Penicillium, and Aspergillus, are the most often occurring producers. Based on their structural characteristics, ergot alkaloids are classified into three groups: peptides, lysergic acid amides, and clavines. The initial metabolic pathways that lead to the formation of the tetracyclic ergoline ring structure are shared by all of them. Different enzymes can alter the ergoline ring in different ways, producing a wide range of naturally occurring bioactive chemicals that are used as precursors or medical treatments. In the present investigation different ergot alkaloids fungus would be taken for the conversion of sugar raw material molasses to ergot alkaloids exposed to different useful molecule under optimized parameters. Ergot alkaloids were the first antimigraine drugs available. Ergot or ergot fungi refers to a group of fungi of the genus Claviceps. Ergot extract has been used in pharmaceutical preparations, including Ergot alkaloids in products such as Cafe got (containing caffeine and ergotamine or ergoline) to treat migraine headaches, and ergometrine, used to induce uterine contractions and to control bleeding after childbirth. In this paper we will discuss. Studies on Fermentative Biotic Production of Ergot Alkaloids.