Studies on the Synthesis, Characterization and Antimicrobial aspects of Sulfur Donor Ligands and their Boron(III) Complexes

Abstract

Biological important complexes of phenyldihydroxyborane derived from 1-acetylferrocene carbodithioic acid (LH) have been prepared and investigated using a combination of microanalytical analysis, melting point, electronic, IR, ¹H NMR and ¹³C NMR spectral studies. Phenyl dihydroxyborane interact with the ligand in 1:1 and 1:2 molar ratios (metal: ligand) resulting in the formation of coloured products.

The ligand are coordinated to the boron (III) via the azomethine nitrogen atom and the thiolic sulfur atom. On the basis of above studies for the Boron (III) complexes are tetra coordinated structure for 1:1 and 1:2 complexes have been assigned.

The antimicrobial activities of the ligand and complexes have been screened in vitro against bacteria Pseudomonas cepacicola and Bacillus substilis and fungi Collectatrichum capsici and Fusarium oxysporum.

The complexes have higher activities than the free ligand. The results of these activities indicate the antiandrogenic nature of these complexes.